The president is expected to talk about the economy on Wednesday.
He'll continue what's become a tradition at the City Club -- several current, former or future presidents have spoken there, including Jimmy Carter, Ronald Reagan, Bill Clinton and both Roosevelts. President George W. Bush addressed a City Club audience in 2006.
City Club CEO Dan Moulthrop says he expects Obama will answer questions from the audience.
"It's been a goal of the City Club to bring the president to Cleveland," Moulthrop said, "and on Wednesday, he's going to do a live, unscripted Q-and-A with the Cleveland community."
Obama last spoke in Cleveland in 2013 at steel plant ArcelorMittal. There he hailed recoveries in manufacturing, and addressed problems with the rollout of the Affordable Care Act.
Correction: While George H.W. Bush did speak at the City Club several times, the Plain Dealer reports he did not do so while serving as president.