The Ohio Department of Rehabilitation and Correction plans to execute Ronald Phillips next month.
When it does, the state plans to use an intravenous administration of midazolam, a sedative and hydromorphone, an opiate.
In recent years, this drug combination has been the backup method for executions, but it has never been used on an Ohio inmate.
The state had to change its previous method for executing inmates when pentobarbital became unavailable for this purpose. Ohio used its last supply of that drug last month during a previous execution.
Ronald Phillips is set to be executed Nov. 14. He was sentenced to death in Summit County for raping, beating and killing the three-year- old daughter of his girlfriend back in 1993.